PHOS-Select Iron Affinity beads enrich peptides for detection of organophosphorus adducts on albumin

Albumin is covalently modified by organophosphorus toxicants (OP) on tyrosine 411, but less than 1% of albumin is modified in humans by lethal OP doses that inhibit 95% of plasma butyrylcholinesterase. A method that enriches OP-modified albumin peptides could aid analysis of low dose exposures. Soma...

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Main Authors: Jiang, Wei, Dubrovskii, Yaroslav A, Podolskaya, Ekaterina P, Murashko, Ekaterina A, Babakov, Vladimir, Nachon, Florian, Masson, Patrick, Schopfer, Lawrence M, Lockridge, Oksana
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886839/
https://ncbi.nlm.nih.gov/pubmed/24187955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400352h
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