Mass Spectrometry Method to Identify Aging Pathways of Sp- and Rp-Tabun Adducts on Human Butyrylcholinesterase Based on the Acid Labile P-N Bond

The phosphoramidate nerve agent tabun inhibits butyrylcholinesterase (BChE) and acetylcholinesterase by making a covalent bond on the active site serine. The adduct loses an alkyl group in a process called aging. The mechanism of aging of the tabun adduct is controversial. Some studies claim that ag...

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Main Authors: Jiang, Wei, Cashman, John R., Nachon, Florian, Masson, Patrick, Schopfer, Lawrence M., Lockridge, Oksana
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595524/
https://ncbi.nlm.nih.gov/pubmed/23345579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft011
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