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Overexpression of Endothelin 1 Triggers Hepatocarcinogenesis in Zebrafish and Promotes Cell Proliferation and Migration through the AKT Pathway

Hepatocarcinogenesis commonly involves the gradual progression from hepatitis to fibrosis and cirrhosis, and ultimately to hepatocellular carcinoma (HCC). Endothelin 1 (Edn1) has been identified as a gene that is significantly up-regulated in HBx-induced HCC in mice. In this study, we further invest...

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Bibliografiske detaljer
Main Authors: Lu, Jeng-Wei, Liao, Chung-Yi, Yang, Wan-Yu, Lin, Yueh-Min, Jin, Shiow-Lian Catherine, Wang, Horng-Dar, Yuh, Chiou-Hwa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885696/
https://ncbi.nlm.nih.gov/pubmed/24416389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085318
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