Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenitor cells (NPCs) derived from FAD mutant PSEN1 s...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Sproul, Andrew A., Jacob, Samson, Pre, Deborah, Kim, Soong Ho, Nestor, Michael W., Navarro-Sobrino, Miriam, Santa-Maria, Ismael, Zimmer, Matthew, Aubry, Soline, Steele, John W., Kahler, David J., Dranovsky, Alex, Arancio, Ottavio, Crary, John F., Gandy, Sam, Noggle, Scott A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885572/
https://ncbi.nlm.nih.gov/pubmed/24416243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084547
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