CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons

Abstract Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol to generate human B...

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Detalhes bibliográficos
Main Authors: Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-10-01
Colecção:Acta Neuropathologica Communications
Assuntos:
Alzheimer’s disease
iPSC
BFCN
CRISPR/Cas9
Electrophysiology
Basal forebrain
Acesso em linha:http://link.springer.com/article/10.1186/s40478-017-0475-z
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