CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol to generate human BFCNs from...

詳細記述

保存先:
書誌詳細
出版年:Acta Neuropathol Commun
主要な著者: Ortiz-Virumbrales, Maitane, Moreno, Cesar L., Kruglikov, Ilya, Marazuela, Paula, Sproul, Andrew, Jacob, Samson, Zimmer, Matthew, Paull, Daniel, Zhang, Bin, Schadt, Eric E., Ehrlich, Michelle E., Tanzi, Rudolph E., Arancio, Ottavio, Noggle, Scott, Gandy, Sam
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2017
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660456/
https://ncbi.nlm.nih.gov/pubmed/29078805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0475-z
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