Alzheimer’s disease PSEN-2 N141I mutation reveals altered and shear-sensitive brain endothelial cell-like phenotype in human iPSC-derived models
Abstract Drug discovery efforts in neurological diseases, such as Alzheimer’s disease (AD), have had particularly poor outcomes due to the lack of models that recapitulate drug interactions at the cerebral vasculature. There is an unmet need to develop physiologically relevant models to study the im...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2025-11-01
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| Serie: | Acta Neuropathologica Communications |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s40478-025-02152-3 |
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