Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenitor cells (NPCs) derived from FAD mutant PSEN1 s...

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Hlavní autoři: Sproul, Andrew A., Jacob, Samson, Pre, Deborah, Kim, Soong Ho, Nestor, Michael W., Navarro-Sobrino, Miriam, Santa-Maria, Ismael, Zimmer, Matthew, Aubry, Soline, Steele, John W., Kahler, David J., Dranovsky, Alex, Arancio, Ottavio, Crary, John F., Gandy, Sam, Noggle, Scott A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885572/
https://ncbi.nlm.nih.gov/pubmed/24416243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084547
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