The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized memory B cells from individuals after primary or secondary infection and analyzed anti-DENV monoclonal antibodies (mAbs...

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Auteurs principaux: Beltramello, Martina, Williams, Katherine L., Simmons, Cameron P., Macagno, Annalisa, Simonelli, Luca, Quyen, Nguyen Than Ha, Sukupolvi-Petty, Soila, Navarro-Sanchez, Erika, Young, Paul R., de Silva, Aravinda M., Rey, Félix A., Varani, Luca, Whitehead, Stephen S., Diamond, Michael S., Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884547/
https://ncbi.nlm.nih.gov/pubmed/20833378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.08.007
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