The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized memory B cells from individuals after primary or secondary infection and analyzed anti-DENV monoclonal antibodies (mAbs...

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主要な著者: Beltramello, Martina, Williams, Katherine L., Simmons, Cameron P., Macagno, Annalisa, Simonelli, Luca, Quyen, Nguyen Than Ha, Sukupolvi-Petty, Soila, Navarro-Sanchez, Erika, Young, Paul R., de Silva, Aravinda M., Rey, Félix A., Varani, Luca, Whitehead, Stephen S., Diamond, Michael S., Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884547/
https://ncbi.nlm.nih.gov/pubmed/20833378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.08.007
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