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Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor (VEGF) favor edema formation, while others such as erythropoietin (Epo) can mitigate it. Both factors are controlled...

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Autors principals: Reischl, Stefan, Li, Lexiao, Walkinshaw, Gail, Flippin, Lee A., Marti, Hugo H., Kunze, Reiner
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883663/
https://ncbi.nlm.nih.gov/pubmed/24409307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084767
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