Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor (VEGF) favor edema formation, while others such as erythropoietin (Epo) can mitigate it. Both factors are controlled...

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Detalhes bibliográficos
Main Authors: Reischl, Stefan, Li, Lexiao, Walkinshaw, Gail, Flippin, Lee A., Marti, Hugo H., Kunze, Reiner
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883663/
https://ncbi.nlm.nih.gov/pubmed/24409307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084767
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