The NLRP3 Inflammasome Promotes Age-related Thymic Demise and Immunosenescence

The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naïve T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in ‘lipotoxic danger signals’ such as free cholesterol (FC) and ceramides, lead...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Youm, Yun-Hee, Kanneganti, Thirumala-Devi, Vandanmagsar, Bolormaa, Zhu, Xuewei, Ravussin, Anthony, Adijiang, Ayinuer, Owen, John S., Thomas, Michael J., Francis, Joseph, Parks, John S., Dixit, Vishwa Deep
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883512/
https://ncbi.nlm.nih.gov/pubmed/22832107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2011.11.005
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires