Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

Clinical evidence that the blockade of IL-1β in type-2 diabetic patients improves glycemia is indicative of an autoinflammatory mechanism that may trigger adiposity-driven pancreatic damage. IL-1β is a key contributor to the obesity-induced inflammation and subsequent insulin resistance, pancreatic...

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Detalles Bibliográficos
Main Authors: Youm, Yun-Hee, Adijiang, Ayinuer, Vandanmagsar, Bolormaa, Burk, David, Ravussin, Anthony, Dixit, Vishwa Deep
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2011
Assuntos:
Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199005/
https://ncbi.nlm.nih.gov/pubmed/21862613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1326
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