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The NLRP3 Inflammasome Promotes Age-related Thymic Demise and Immunosenescence
The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naïve T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in ‘lipotoxic danger signals’ such as free cholesterol (FC) and ceramides, lead...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3883512/ https://ncbi.nlm.nih.gov/pubmed/22832107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2011.11.005 |
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