Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti–hepatitis C virus (HCV)–positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%;...

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Main Authors: Aka, Peter V., Kuniholm, Mark H., Pfeiffer, Ruth M., Wang, Alan S., Tang, Wei, Chen, Sabrina, Astemborski, Jacquie, Plankey, Michael, Villacres, Maria C., Peters, Marion G., Desai, Seema, Seaberg, Eric C., Edlin, Brian R., Strickler, Howard D., Thomas, David L., Prokunina-Olsson, Ludmila, Sharp, Gerald B., O'Brien, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883162/
https://ncbi.nlm.nih.gov/pubmed/23956438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit433
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