Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice

Patients with obstructive sleep apnea, who experience episodic hypoxia and hypercapnia during sleep, often demonstrate increased inflammation, oxidative stress, and dyslipidemia. We hypothesized that sleep apnea patients would be predisposed to the development of atherosclerosis. To dissect the mech...

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Main Authors: Douglas, Robert M., Bowden, Karen, Pattison, Jennifer, Peterson, Alexander B., Juliano, Joseph, Dalton, Nancy D., Gu, Yusu, Alvarez, Erika, Imamura, Toshihiro, Peterson, Kirk L., Witztum, Joseph L., Haddad, Gabriel G., Li, Andrew C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2013
נושאים:
Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882740/
https://ncbi.nlm.nih.gov/pubmed/23990245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00442.2013
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