Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice

Patients with obstructive sleep apnea, who experience episodic hypoxia and hypercapnia during sleep, often demonstrate increased inflammation, oxidative stress, and dyslipidemia. We hypothesized that sleep apnea patients would be predisposed to the development of atherosclerosis. To dissect the mech...

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Detalhes bibliográficos
Main Authors: Douglas, Robert M., Bowden, Karen, Pattison, Jennifer, Peterson, Alexander B., Juliano, Joseph, Dalton, Nancy D., Gu, Yusu, Alvarez, Erika, Imamura, Toshihiro, Peterson, Kirk L., Witztum, Joseph L., Haddad, Gabriel G., Li, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882740/
https://ncbi.nlm.nih.gov/pubmed/23990245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00442.2013
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