Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke

Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy metabolites. The primary goals of this study were to investigate the effects of acute sEH inhibition by trans-4-[4-(3-adamantan-1-yl-ureido)-cycl...

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Detalhes bibliográficos
Main Authors: Shaik, Jafar Sadik B., Ahmad, Muzamil, Li, Wenjin, Rose, Marie E., Foley, Lesley M., Hitchens, T. Kevin, Graham, Steven H., Hwang, Sung Hee, Hammock, Bruce D., Poloyac, Samuel M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882464/
https://ncbi.nlm.nih.gov/pubmed/24043255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00471.2013
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