Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke

Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy metabolites. The primary goals of this study were to investigate the effects of acute sEH inhibition by trans-4-[4-(3-adamantan-1-yl-ureido)-cycl...

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Hlavní autoři: Shaik, Jafar Sadik B., Ahmad, Muzamil, Li, Wenjin, Rose, Marie E., Foley, Lesley M., Hitchens, T. Kevin, Graham, Steven H., Hwang, Sung Hee, Hammock, Bruce D., Poloyac, Samuel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Vascular Biology and Microcirculation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882464/
https://ncbi.nlm.nih.gov/pubmed/24043255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00471.2013
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