Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido) dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

The soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in blood pressure regulation and vascular inflammation. 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA, 1) is a very active inhibitor of sEH both in vitro and in vivo. However,...

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Main Authors: Kim, In-Hae, Nishi, Kosuke, Tsai, Hsing-Ju, Bradford, Tanya, Koda, Yasuko, Watanabe, Takaho, Morisseau, Christophe, Blanchfield, Joanne, Toth, Istvan, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040326/
https://ncbi.nlm.nih.gov/pubmed/17046265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.09.057
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