Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin

BACKGROUND: To explore whether combining inhibitors that target the insulin-like growth factor receptor (IGFR)/PI3K/Akt/mTOR signaling pathway (vertical blockade) can improve treatment efficacy for hepatocellular carcinoma (HCC). METHODS: HCC cell lines (including Hep3B, Huh7, and PLC5) and HUVECs (...

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Detalhes bibliográficos
Main Authors: Ou, Da-Liang, Lee, Bin-Shyun, Lin, Liang-In, Liou, Jun-Yang, Liao, Sheng-Chieh, Hsu, Chiun, Cheng, Ann-Lii
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882101/
https://ncbi.nlm.nih.gov/pubmed/24387108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-2
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