Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

BACKGROUND: Severe atopic conditions associated with elevated serum IgE are heterogeneous with few known causes. Nearly every patient with autosomal-dominant hyper-IgE syndrome (AD-HIES) due to signal transducer and activator of transcription 3 (STAT3) mutations has a history of eczematous dermatiti...

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Hlavní autoři: Siegel, Andrea M., Stone, Kelly D., Cruse, Glenn, Lawrence, Monica G., Olivera, Ana, Jung, Mi-yeon, Barber, John S., Freeman, Alexandra F., Holland, Steven M., O’Brien, Michelle, Jones, Nina, Wisch, Laura B., Kong, Heidi H., Desai, Avanti, Farber, Orly, Gilfillan, Alasdair M., Rivera, Juan, Milner, Joshua D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881191/
https://ncbi.nlm.nih.gov/pubmed/24184145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.08.045
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