Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast-cell TNF-α production

Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, w...

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Detalhes bibliográficos
Main Authors: Medic, Nevenka, Desai, Avanti, Olivera, Ana, Abramowitz, Joel, Birnbaumer, Lutz, Beaven, Michael A., Gilfillan, Alasdair M., Metcalfe, Dean D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665697/
https://ncbi.nlm.nih.gov/pubmed/23489970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2013.02.001
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