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A Preparation of (−)-Nutlin-3 Using Enantioselective Organocatalysis at Decagram Scale
[Image: see text] Chiral nonracemic cis-4,5-bis(aryl) imidazolines have emerged as a powerful platform for the development of cancer chemotherapeutics, stimulated by the Hoffmann-La Roche discovery that Nutlin-3 can restore apoptosis in cells with wild-type p53. The lack of efficient methods for the...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880828/ https://ncbi.nlm.nih.gov/pubmed/24127627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo401321a |
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