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Stable insulin secreting ducts formed by reprogramming of cells in the liver using a three gene cocktail and a PPAR agonist

With the long term aim of developing a new type of therapy for diabetes, we have investigated the reprogramming of liver cells in normal mice towards a pancreatic phenotype using the gene combination Pdx1, Ngn3, MafA. CD1 mice were rendered diabetic with streptozotocin and given a single dose of Ad-...

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Autors principals: Banga, Anannya, Greder, Lucas V., Dutton, James R., Slack, Jonathan M.W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880604/
https://ncbi.nlm.nih.gov/pubmed/24089243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.50
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