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Role of SOX2 in the Etiology of Embryonal Carcinoma, Based on Analysis of the NCCIT and NT2 Cell Lines

The transcription factor SOX2, associated with amongst others OCT3/4, is essential for maintenance of pluripotency and self-renewal of embryonic stem cells. SOX2 is highly expressed in embryonal carcinoma (EC), the stem cell component of malignant nonseminomatous germ cell tumors, referred to as ger...

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Detalhes bibliográficos
Main Authors: Eini, Ronak, Stoop, Hans, Gillis, Ad J. M., Biermann, Katharina, Dorssers, Lambert C. J., Looijenga, Leendert H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880257/
https://ncbi.nlm.nih.gov/pubmed/24404135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083585
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