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Mechanism-based inhibition of quinone reductase 2 (NQO2). Selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition
A role for the flavoprotein NRH:quinone oxidoreductase 2 (NQO2, QR2) in human diseases such as malaria, leukemia and neurodegeneration has been proposed. In order to explore the potential of NQO2 as a therapeutic target, we have developed potent and selective mechanism-based inhibitors centered on t...
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Main Authors: | , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2011
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880221/ https://ncbi.nlm.nih.gov/pubmed/21506232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100085 |
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