Indolequinone Inhibitors of NRH:Quinone Oxidoreductase 2 (NQO2). Characterization of Mechanism of Inhibition in both Cell-free and Cellular Systems.

We describe a series of indolequinones as efficient mechanism-based inhibitors of NRH:quinone oxidoreductase 2 (NQO2) for use either in cellular or cell-free systems. Compounds were designed to be reduced in the active site of the enzyme leading to loss of a substituted phenol leaving group and gene...

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Main Authors: Yan, Chao, Dufour, Marine, Siegel, David, Reigan, Philip, Gomez, Joe, Shieh, Biehuoy, Moody, Christopher J., Ross, David
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291479/
https://ncbi.nlm.nih.gov/pubmed/21718050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2002967
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