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Indolequinone Inhibitors of NRH:Quinone Oxidoreductase 2 (NQO2). Characterization of Mechanism of Inhibition in both Cell-free and Cellular Systems.

We describe a series of indolequinones as efficient mechanism-based inhibitors of NRH:quinone oxidoreductase 2 (NQO2) for use either in cellular or cell-free systems. Compounds were designed to be reduced in the active site of the enzyme leading to loss of a substituted phenol leaving group and gene...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Yan, Chao, Dufour, Marine, Siegel, David, Reigan, Philip, Gomez, Joe, Shieh, Biehuoy, Moody, Christopher J., Ross, David
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291479/
https://ncbi.nlm.nih.gov/pubmed/21718050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2002967
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