Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

[Image: see text] Detoxicating enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like compounds. The protective role of the polymorphic NQO1 and NQO2 enzymes is especially of interest in the liver as the major site...

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Gepubliceerd in:Chem Res Toxicol
Hoofdauteurs: den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Toorneman, Robin M., van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J., Vermeulen, Nico P. E., Commandeur, Jan N. M., Vos, J. Chris
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2017
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997408/
https://ncbi.nlm.nih.gov/pubmed/29281794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00289
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