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Mechanism-based inhibition of quinone reductase 2 (NQO2). Selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition

A role for the flavoprotein NRH:quinone oxidoreductase 2 (NQO2, QR2) in human diseases such as malaria, leukemia and neurodegeneration has been proposed. In order to explore the potential of NQO2 as a therapeutic target, we have developed potent and selective mechanism-based inhibitors centered on t...

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書誌詳細
主要な著者: Dufour, Marine, Yan, Chao, Siegel, David, Colucci, Marie A., Jenner, Matthew, Oldham, Neil J., Gomez, Joe, Reigan, Philip, Li, Yazhuo, De Matteis, Cristina I., Ross, David, Moody, Christopher J.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880221/
https://ncbi.nlm.nih.gov/pubmed/21506232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100085
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