Enhancement of tumor-reactive cytotoxic CD4(+) T cell responses after ipilimumab treatment in four advanced melanoma patients

CD4(+) T cells provide help to enhance and sustain cytotoxic CD8(+) T cell responses. A direct lytic role for this cell population in mouse models further supports the use of tumor-reactive CD4(+) T cells for cancer immunotherapy. CTLA-4 blockade has been shown to expand antigen-specific cytotoxic C...

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Autori principali: Kitano, Shigehisa, Tsuji, Takemasa, Liu, Caillian, Hirschhorn-Cymerman, Daniel, Kyi, Chrisann, Mu, Zhenyu, Allison, James P., Gnjatic, Sacha, Yuan, Jianda D., Wolchok, Jedd D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880021/
https://ncbi.nlm.nih.gov/pubmed/24396833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0068
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