VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

Innate immune cells play a major role in the early response to myocardial ischemia/reperfusion (MI/R) injury. Recombinant human ADAMTS13 (rhADAMTS13), cleaving von Willebrand factor (VWF), reduces leukocyte recruitment in mice. Death of cardiomyocytes and the possible formation of neutrophil extrace...

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Main Authors: Savchenko, Alexander S., Borissoff, Julian I., Martinod, Kimberly, De Meyer, Simon F., Gallant, Maureen, Erpenbeck, Luise, Brill, Alexander, Wang, Yanming, Wagner, Denisa D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Vascular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879903/
https://ncbi.nlm.nih.gov/pubmed/24200682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-514992
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