PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

Neutrophil extracellular traps (NETs), consisting of nuclear DNA with histones and microbicidal proteins, are expelled from activated neutrophils during sepsis. NETs were shown to trap microbes, but they also fuel cardiovascular, thrombotic, and autoimmune disease. The role of NETs in sepsis, partic...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Martinod, Kimberly, Fuchs, Tobias A., Zitomersky, Naamah L., Wong, Siu Ling, Demers, Melanie, Gallant, Maureen, Wang, Yanming, Wagner, Denisa D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Phagocytes, Granulocytes, and Myelopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366625/
https://ncbi.nlm.nih.gov/pubmed/25624317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587709
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