Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes

Selenoprotein P (SeP; encoded by SEPP1 in humans) is a liver-derived secretory protein that induces insulin resistance in type 2 diabetes. Suppression of SeP might provide a novel therapeutic approach to treating type 2 diabetes, but few drugs that inhibit SEPP1 expression in hepatocytes have been i...

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Main Authors: Takayama, Hiroaki, Misu, Hirofumi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Murao, Koji, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Saito, Reina, Tajima, Natsumi, Shirasaki, Takayoshi, Matsugo, Seiichi, Miyamoto, Ken-ichi, Kaneko, Shuichi, Takamura, Toshinari
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879556/
https://ncbi.nlm.nih.gov/pubmed/24257750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479386
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