Concentration-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes

BACKGROUND: Oxidative stress induced by the accumulation of reactive oxygen species (ROS) has a causal role in the development of insulin resistance, whereas ROS themselves function as intracellular second messengers that promote insulin signal transduction. ROS can act both positively and negativel...

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Main Authors: Iwakami, Satoshi, Misu, Hirofumi, Takeda, Takashi, Sugimori, Makoto, Matsugo, Seiichi, Kaneko, Shuichi, Takamura, Toshinari
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216925/
https://ncbi.nlm.nih.gov/pubmed/22102892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027401
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