Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes

Selenoprotein P (encoded by SELENOP in humans, Selenop in rat), a liver-derived secretory protein, induces resistance to insulin and vascular endothelial growth factor (VEGF) in type 2 diabetes. Suppression of selenoprotein P may provide a novel therapeutic approach to treating type 2 diabetes; howe...

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Vydáno v:J Biol Chem
Hlavní autoři: Tajima-Shirasaki, Natsumi, Ishii, Kiyo-aki, Takayama, Hiroaki, Shirasaki, Takayoshi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Iwasaki, Yasumasa, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Takeshita, Yumie, Murao, Koji, Matsugo, Seiichi, Kaneko, Shuichi, Misu, Hirofumi, Takamura, Toshinari
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491766/
https://ncbi.nlm.nih.gov/pubmed/28465347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747006
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