Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems

Por Liu, Fanwei, Shimakami, Tetsuro, Murai, Kazuhisa, Shirasaki, Takayoshi, Funaki, Masaya, Honda, Masao, Murakami, Seishi, Yi, Minkyung, Tang, Hong, Kaneko, Shuichi
Publicado no Sci Rep (2016)

Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice

Por Okada, Hikari, Honda, Masao, Campbell, Jean S, Takegoshi, Kai, Sakai, Yoshio, Yamashita, Taro, Shirasaki, Takayoshi, Takabatake, Riuta, Nakamura, Mikiko, Tanaka, Takuji, Kaneko, Shuichi
Publicado no Cancer Sci (2015)

Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro

Por Murai, Kazuhisa, Shirasaki, Takayoshi, Honda, Masao, Shimizu, Ryogo, Shimakami, Tetsuro, Nakasho, Saki, Shirasaki, Natsumi, Okada, Hikari, Sakai, Yoshio, Yamashita, Taro, Kaneko, Shuichi
Publicado no Int J Mol Sci (2018)

The Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro

Por Shimakami, Tetsuro, Honda, Masao, Shirasaki, Takayoshi, Takabatake, Riuta, Liu, Fanwei, Murai, Kazuhisa, Shiomoto, Takayuki, Funaki, Masaya, Yamane, Daisuke, Murakami, Seishi, Lemon, Stanley M., Kaneko, Shuichi
Publicado em 2014

Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet

Por Okada, Hikari, Takabatake, Riuta, Honda, Masao, Takegoshi, Kai, Yamashita, Taro, Nakamura, Mikiko, Shirasaki, Takayoshi, Sakai, Yoshio, Shimakami, Tetsuro, Nagata, Naoto, Takamura, Toshinari, Tanaka, Takuji, Kaneko, Shuichi
Publicado no Oncotarget (2017)

Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus

Por Murai, Kazuhisa, Shimakami, Tetsuro, Welsch, Christoph, Shirasaki, Takayoshi, Liu, Fanwei, Kitabayashi, Juria, Tanaka, Shiho, Funaki, Masaya, Omura, Hitoshi, Nishikawa, Tomoki, Sumiyadorj, Ariunaa, Honda, Masao, Kaneko, Shuichi
Publicado no Antimicrob Agents Chemother (2018)

Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation

Por Wang, Zijing, Kawaguchi, Kazunori, Honda, Masao, Hashimoto, Shinichi, Shirasaki, Takayoshi, Okada, Hikari, Orita, Noriaki, Shimakami, Tetsuro, Yamashita, Taro, Sakai, Yoshio, Mizukoshi, Eishiro, Murakami, Seishi, Kaneko, Shuichi
Publicado no Sci Rep (2019)

MicroRNA-27a Regulates Lipid Metabolism and Inhibits Hepatitis C Virus Replication in Human Hepatoma Cells

Por Shirasaki, Takayoshi, Honda, Masao, Shimakami, Tetsuro, Horii, Rika, Yamashita, Taro, Sakai, Yoshio, Sakai, Akito, Okada, Hikari, Watanabe, Risa, Murakami, Seishi, Yi, MinKyung, Lemon, Stanley M., Kaneko, Shuichi
Publicado em 2013

Establishment and Characterization of a New Cell Line Permissive for Hepatitis C Virus Infection

Por Omura, Hitoshi, Liu, Fanwei, Shimakami, Tetsuro, Murai, Kazuhisa, Shirasaki, Takayoshi, Kitabayashi, Juria, Funaki, Masaya, Nishikawa, Tomoki, Nakai, Ryotaro, Sumiyadorj, Ariunaa, Hayashi, Takehiro, Yamashita, Taro, Honda, Masao, Kaneko, Shuichi
Publicado no Sci Rep (2019)

Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model

Por Takegoshi, Kai, Honda, Masao, Okada, Hikari, Takabatake, Riuta, Matsuzawa-Nagata, Naoto, Campbell, Jean S., Nishikawa, Masashi, Shimakami, Tetsuro, Shirasaki, Takayoshi, Sakai, Yoshio, Yamashita, Taro, Takamura, Toshinari, Tanaka, Takuji, Kaneko, Shuichi
Publicado no Oncotarget (2017)

Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Por Funaki, Masaya, Kitabayashi, Juria, Shimakami, Tetsuro, Nagata, Naoto, Sakai, Yuriko, Takegoshi, Kai, Okada, Hikari, Murai, Kazuhisa, Shirasaki, Takayoshi, Oyama, Takeru, Yamashita, Taro, Ota, Tsuguhito, Takuwa, Yoh, Honda, Masao, Kaneko, Shuichi
Publicado no Sci Rep (2017)

The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

Por Shirasaki, Takayoshi, Honda, Masao, Yamashita, Taro, Nio, Kouki, Shimakami, Tetsuro, Shimizu, Ryougo, Nakasyo, Saki, Murai, Kazuhisa, Shirasaki, Natsumi, Okada, Hikari, Sakai, Yoshio, Sato, Tokiharu, Suzuki, Tetsuro, Yoshioka, Katsuji, Kaneko, Shuichi
Publicado no Sci Rep (2018)

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

Por Selitsky, Sara R., Baran-Gale, Jeanette, Honda, Masao, Yamane, Daisuke, Masaki, Takahiro, Fannin, Emily E., Guerra, Bernadette, Shirasaki, Takayoshi, Shimakami, Tetsuro, Kaneko, Shuichi, Lanford, Robert E., Lemon, Stanley M., Sethupathy, Praveen
Publicado no Sci Rep (2015)

MicroRNA‐10a Impairs Liver Metabolism in Hepatitis C Virus‐Related Cirrhosis Through Deregulation of the Circadian Clock Gene Brain and Muscle Aryl Hydrocarbon Receptor Nuclear Tra...

Por Horii, Rika, Honda, Masao, Shirasaki, Takayoshi, Shimakami, Tetsuro, Shimizu, Ryogo, Yamanaka, Souma, Murai, Kazuhisa, Kawaguchi, Kazunori, Arai, Kuniaki, Yamashita, Tatsuya, Sakai, Yoshio, Yamashita, Taro, Okada, Hikari, Nakamura, Mikiko, Mizukoshi, Eishiro, Kaneko, Shuichi
Publicado no Hepatol Commun (2019)

DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells

Por Hashimoto, Shinichi, Shirasaki, Takayoshi, Yamashita, Taro, Iwabuchi, Sadahiro, Suzuki, Yutaka, Takamura, Yuzuru, Ukita, Yoshiaki, Deshimaru, Shungo, Okayama, Toshitugu, Ikeo, Kazuho, Kuroki, Kazuyuki, Kawaguchi, Kazunori, Mizukoshi, Eishiro, Matsushima, Kouji, Honda, Masao, Kaneko, Shuichi
Publicado no PLoS One (2021)

Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes

Por Takayama, Hiroaki, Misu, Hirofumi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Murao, Koji, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Saito, Reina, Tajima, Natsumi, Shirasaki, Takayoshi, Matsugo, Seiichi, Miyamoto, Ken-ichi, Kaneko, Shuichi, Takamura, Toshinari
Publicado em 2014

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepa...

Por Tajima-Shirasaki, Natsumi, Ishii, Kiyo-aki, Takayama, Hiroaki, Shirasaki, Takayoshi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Iwasaki, Yasumasa, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Takeshita, Yumie, Murao, Koji, Matsugo, Seiichi, Kaneko, Shuichi, Misu, Hirofumi, Takamura, Toshinari
Publicado no J Biol Chem (2017)

Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection

Por Murata, Kazumoto, Asano, Mai, Matsumoto, Akihiro, Sugiyama, Masaya, Nishida, Nao, Tanaka, Eiji, Inoue, Taisuke, Sakamoto, Minoru, Enomoto, Nobuyuki, Shirasaki, Takayoshi, Honda, Masao, Kaneko, Shuichi, Gatanaga, Hiroyuki, Oka, Shinichi, Kawamura, Yuki I, Dohi, Taeko, Shuno, Yasutaka, Yano, Hideaki, Mizokami, Masashi
Publicado no Gut (2018)