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Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection
Highly pathogenic avian influenza viruses (HPAIV) induce severe inflammation in poultry and men. One characteristic of HPAIV infections is the induction of a cytokine burst that strongly contributes to viral pathogenicity. This cell-intrinsic hypercytokinemia seems to involve hyperinduction of p38 m...
Kaydedildi:
Asıl Yazarlar: | , , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2014
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879537/ https://ncbi.nlm.nih.gov/pubmed/24189062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469239 |
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