Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection

Highly pathogenic avian influenza viruses (HPAIV) induce severe inflammation in poultry and men. One characteristic of HPAIV infections is the induction of a cytokine burst that strongly contributes to viral pathogenicity. This cell-intrinsic hypercytokinemia seems to involve hyperinduction of p38 m...

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Detalhes bibliográficos
Main Authors: Börgeling, Yvonne, Schmolke, Mirco, Viemann, Dorothee, Nordhoff, Carolin, Roth, Johannes, Ludwig, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879537/
https://ncbi.nlm.nih.gov/pubmed/24189062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469239
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