Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4)

The MEK5/Erk5 MAPK cascade has recently been implicated in the regulation of endothelial integrity and represents a candidate pathway mediating the beneficial effects of laminar flow, a major factor preventing vascular dysfunction and disease. Here we expressed a constitutively active mutant of MEK5...

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Autors principals: Ohnesorge, Nils, Viemann, Dorothee, Schmidt, Nicole, Czymai, Tobias, Spiering, Désirée, Schmolke, Mirco, Ludwig, Stephan, Roth, Johannes, Goebeler, Matthias, Schmidt, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924030/
https://ncbi.nlm.nih.gov/pubmed/20551324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103127
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