STAT4 Associates with SLE Through Two Independent Effects that Correlate with Gene Expression and Act Additively with IRF5 to Increase Risk

OBJECTIVES: To confirm and define the genetic association of STAT4 and systemic lupus erythematosus, investigate the possibility of correlations with differential splicing and/or expression levels, and genetic interaction with IRF5. METHODS: 30 tag SNPs were genotyped in an independent set of Spanis...

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Autori principali: Abelson, Anna-Karin, Delgado-Vega, Angélica M., Kozyrev, Sergey V., Sánchez, Elena, Velázquez-Cruz, Rafael, Eriksson, Niclas, Wojcik, Jerome, Reddy, Prasad Linga, Lima, Guadalupe, D’Alfonso, Sandra, Migliaresi, Sergio, Baca, Vicente, Orozco, Lorena, Witte, Torsten, Ortego-Centeno, Norberto, Abderrahim, Hadi, Pons-Estel, Bernardo A., Gutiérrez, Carmen, Suárez, Ana, González-Escribano, Maria Francisca, Martin, Javier, Alarcón-Riquelme, Marta E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878433/
https://ncbi.nlm.nih.gov/pubmed/19019891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2008.097642
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