Genetic association of miRNA146a with Systemic Lupus Erythematosus in Europeans through decreased expression of the gene

A recent genome-wide association study revealed a variant (rs2431697) in an intergenic region, between the PTTG1 and microRNA (miR-146a) genes, associated with SLE susceptibility. Here, we analyzed with a case-control design this variant and other candidate polymorphisms in this region together with...

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Main Authors: Löfgren, Sara E., Frostegård, Johan, Truedsson, Lennart, Pons-Estel, Bernardo A., D’Alfonso, Sandra, Witte, Torsten, Lauwerys, Bernard R., Endreffy, Emoke, Kovács, László, Vasconcelos, Carlos, da Silva, Berta Martins, Kozyrev, Sergey V., Alarcón-Riquelme, Marta E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640319/
https://ncbi.nlm.nih.gov/pubmed/22218224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2011.84
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