IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE

Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk haplotype is common across populations, yet immune functions for the risk haplotype are undefined. We characterized the g...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Li, Dan, Matta, Bharati, Song, Su, Nelson, Victoria, Diggins, Kirsten, Simpfendorfer, Kim R., Gregersen, Peter K., Linsley, Peter, Barnes, Betsy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098722/
https://ncbi.nlm.nih.gov/pubmed/31877114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124020
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