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Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases
In eukaryotes, the poly(A) tail added at the 3′ end of a mRNA precursor is essential for the regulation of mRNA stability and the initiation of translation. Poly(A) polymerase (PAP) is the enzyme that catalyzes the poly(A) addition reaction. Multiple isoforms of PAP have been identified in vertebrat...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3878066/ https://ncbi.nlm.nih.gov/pubmed/24076191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.09.025 |
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