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Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a ‘DNA-strand break sensor’, which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which pr...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373339/ https://ncbi.nlm.nih.gov/pubmed/14739238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh215 |
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