Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a ‘DNA-strand break sensor’, which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which pr...

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izdano v:	Nucleic Acids Res
Principais autores:	Oliver, Antony W., Amé, Jean-Christophe, Roe, S. Mark, Good, Valerie, de Murcia, Gilbert, Pearl, Laurence H.
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2004
Teme:	Articles
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373339/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14739238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh215
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