Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer

Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified in various cancers. We investigated FLIP and procaspase-8 expression in NSCL...

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Bibliografiske detaljer
Main Authors: Riley, J S, Hutchinson, R, McArt, D G, Crawford, N, Holohan, C, Paul, I, Van Schaeybroeck, S, Salto-Tellez, M, Johnston, P G, Fennell, D A, Gately, K, O'Byrne, K, Cummins, R, Kay, E, Hamilton, P, Stasik, I, Longley, D B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877552/
https://ncbi.nlm.nih.gov/pubmed/24309938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.481
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