Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

Death receptor activation triggers recruitment of FADD, which via its death effector domain (DED) engages DEDs in procaspase 8 and its inhibitor FLIP to form death-inducing signalling complexes (DISCs). The DEDs of FADD, FLIP and procaspase 8 interact with one another using two binding surfaces defi...

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Detalhes bibliográficos
Main Authors: Majkut, J, Sgobba, M, Holohan, C, Crawford, N, Logan, AE, Kerr, E, Higgins, CA, Redmond, KL, Riley, JS, Stasik, I, Fennell, DA, Van Schaeybroeck, S, Haider, S, Johnston, PG, Haigh, D, Longley, DB
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942653/
https://ncbi.nlm.nih.gov/pubmed/24577104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4350
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