Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

FLIP is a potential anti-cancer therapeutic target that inhibits apoptosis by blocking caspase 8 activation by death receptors. We report a novel interaction between FLIP and the DNA repair protein Ku70 that regulates FLIP protein stability by inhibiting its polyubiquitination. Furthermore, we found...

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Detalhes bibliográficos
Principais autores: Kerr, E, Holohan, C, McLaughlin, K M, Majkut, J, Dolan, S, Redmond, K, Riley, J, McLaughlin, K, Stasik, I, Crudden, M, Van Schaeybroeck, S, Fenning, C, O'Connor, R, Kiely, P, Sgobba, M, Haigh, D, Johnston, P G, Longley, D B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392639/
https://ncbi.nlm.nih.gov/pubmed/22322857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.8
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