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GIT1 Activates p21-Activated Kinase through a Mechanism Independent of p21 Binding

p21-activated kinases (PAKs) associate with a guanine nucleotide exchange factor, Pak-interacting exchange factor (PIX), which in turn binds the paxillin-associated adaptor GIT1 that targets the complex to focal adhesions. Here, a detailed structure-function analysis of GIT1 reveals how this multido...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Loo, Tsui-Han, Ng, Yuen-Wai, Lim, Louis, Manser, Ed
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC387736/
https://ncbi.nlm.nih.gov/pubmed/15082779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3849-3859.2004
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